abstract：BACKGROUND:It is unclear whether the incidence of non-valvular atrial fibrillation (NVAF) has been increasing over time. We aimed to provide contemporary estimates of the incidence and case-fatality of NVAF in a well-defined population. METHODS AND RESULTS:We used the computerized databases of the Régie de l'assurance...

journal_title：Journal of the American Heart Association

authors： Renoux C,Patenaude V,Suissa S

更新日期：2014-11-03 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is associated with increased risk of hospitalization. Little is known about the impact of AF on utilization of noninpatient health care or about sex or race differences in AF-related utilization. We examined rates of inpatient and outpatient utilization by AF status in the Atheroscle...

journal_title：Journal of the American Heart Association

authors： Bengtson LG,Lutsey PL,Loehr LR,Kucharska-Newton A,Chen LY,Chamberlain AM,Wruck LM,Duval S,Stearns SC,Alonso A

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND:Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large a...

journal_title：Journal of the American Heart Association

authors： Galindo CL,Kasasbeh E,Murphy A,Ryzhov S,Lenihan S,Ahmad FA,Williams P,Nunnally A,Adcock J,Song Y,Harrell FE,Tran TL,Parry TJ,Iaci J,Ganguly A,Feoktistov I,Stephenson MK,Caggiano AO,Sawyer DB,Cleator JH

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:It is uncertain whether sex and race affect thrombogenicity in patients with coronary artery disease. We evaluated the effects of sex and race on thrombogenicity in patients with coronary artery disease treated with aspirin. METHODS AND RESULTS:Patients on aspirin therapy for 1 week or longer with known or ...

journal_title：Journal of the American Heart Association

authors： Lev EI,Bliden KP,Jeong YH,Pandya S,Kang K,Franzese C,Tantry US,Gurbel PA

更新日期：2014-10-20 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a common condition associated with cardiovascular disease. Its potential effect on progression of subclinical atherosclerosis is not well understood. We tested the hypothesis that self-reported OSA is associated with progression of coronary artery calcium (CAC). We also evalu...

journal_title：Journal of the American Heart Association

authors： Kwon Y,Duprez DA,Jacobs DR,Nagayoshi M,McClelland RL,Shahar E,Budoff M,Redline S,Shea S,Carr JJ,Lutsey PL

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:Glycosylated proteins partake in multiple cellular processes including inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N-acetyl groups, is related to incident cardiovascular disease (CVD), and we compared it with high-sensitivity C-reactive protein (hsCRP). METHODS AND RESULTS:...

journal_title：Journal of the American Heart Association

authors： Akinkuolie AO,Buring JE,Ridker PM,Mora S

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Impaired generation and signaling of nitric oxide (NO) contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent CVR factor. Many processes involved in ...

journal_title：Journal of the American Heart Association

authors： Sverdlov AL,Ngo DT,Chan WP,Chirkov YY,Horowitz JD

更新日期：2014-08-18 00:00:00

abstract：BACKGROUND:Galectin-3 (Gal-3) participates in different mechanisms involved in atherothrombosis, such as inflammation, proliferation, or macrophage chemotaxis. Thus, there have been committed intensive efforts to elucidate the function of Gal-3 in cardiovascular (CV) diseases. The role of Gal-3 as a circulating biomark...

journal_title：Journal of the American Heart Association

authors： Madrigal-Matute J,Lindholt JS,Fernandez-Garcia CE,Benito-Martin A,Burillo E,Zalba G,Beloqui O,Llamas-Granda P,Ortiz A,Egido J,Blanco-Colio LM,Martin-Ventura JL

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:Sedentary behaviors have been directly associated with all-cause mortality. However, little is known about different types of sedentary behaviors in relation to overall mortality. Our objective was to assess the association between different sedentary behaviors and all-cause mortality. METHODS AND RESULTS:I...

journal_title：Journal of the American Heart Association

authors： Basterra-Gortari FJ,Bes-Rastrollo M,Gea A,Núñez-Córdoba JM,Toledo E,Martínez-González MÁ

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. METHODS AND RESULTS:We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=4...

journal_title：Journal of the American Heart Association

authors： Burch PT,Gerstenberger E,Ravishankar C,Hehir DA,Davies RR,Colan SD,Sleeper LA,Newburger JW,Clabby ML,Williams IA,Li JS,Uzark K,Cooper DS,Lambert LM,Pemberton VL,Pike NA,Anderson JB,Dunbar-Masterson C,Khaikin S,Zyble

更新日期：2014-06-23 00:00:00

abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

journal_title：Journal of the American Heart Association

authors： Sartipy U,Goda A,Mancini DM,Lund LH

更新日期：2014-06-06 00:00:00

abstract：BACKGROUND:Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to...

journal_title：Journal of the American Heart Association

authors： Rain S,Bos Dda S,Handoko ML,Westerhof N,Stienen G,Ottenheijm C,Goebel M,Dorfmüller P,Guignabert C,Humbert M,Bogaard HJ,Remedios CD,Saripalli C,Hidalgo CG,Granzier HL,Vonk-Noordegraaf A,van der Velden J,de Man FS

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:Higher heart rate has been associated with an adverse prognosis, but most prior studies focused on individuals with known cardiovascular disease or examined a limited number of outcomes. We sought to examine the association of baseline heart rate with both fatal and nonfatal outcomes during 2 decades of foll...

journal_title：Journal of the American Heart Association

authors： Ho JE,Larson MG,Ghorbani A,Cheng S,Coglianese EE,Vasan RS,Wang TJ

更新日期：2014-05-08 00:00:00

abstract：BACKGROUND:The impact of dispatcher-assisted bystander cardiopulmonary resuscitation (CPR) on neurological outcomes in children is unclear. We investigated whether dispatcher-assisted bystander CPR shows favorable neurological outcomes (Cerebral Performance Category scale 1 or 2) in children with out-of-hospital cardia...

journal_title：Journal of the American Heart Association

authors： Goto Y,Maeda T,Goto Y

更新日期：2014-04-30 00:00:00

abstract：BACKGROUND:Decreased arterial elasticity is a risk factor for several cardiovascular outcomes. Longitudinal data on the effect of physical activity in youth on adult arterial elasticity are limited. The aim of this study was to determine the long-term effects of physical activity in children and young adults on carotid...

journal_title：Journal of the American Heart Association

authors： Pälve KS,Pahkala K,Magnussen CG,Koivistoinen T,Juonala M,Kähönen M,Lehtimäki T,Rönnemaa T,Viikari JS,Raitakari OT

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Identifying the best markers to judge the adequacy of lipid-lowering treatment is increasingly important for coronary heart disease (CHD) prevention given that several novel, potent lipid-lowering therapies are in development. Reductions in LDL-C, non-HDL-C, or apoB can all be used but which most closely rel...

journal_title：Journal of the American Heart Association

authors： Thanassoulis G,Williams K,Ye K,Brook R,Couture P,Lawler PR,de Graaf J,Furberg CD,Sniderman A

更新日期：2014-04-14 00:00:00

abstract：BACKGROUND:Inappropriate sinus tachycardia (IST) and postural tachycardia syndrome (POTS) are 2 disorders characterized by sinus tachycardia. It is debated whether the pathophysiology of IST and POTS results from abnormal autonomic regulation or abnormal sinus node function. We hypothesized that intrinsic heart rate (I...

journal_title：Journal of the American Heart Association

authors： Nwazue VC,Paranjape SY,Black BK,Biaggioni I,Diedrich A,Dupont WD,Robertson D,Raj SR

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Clinical symptoms are part of the risk stratification approaches used in the emergency department (ED) to evaluate patients with suspected acute coronary syndromes (ACS). The objective of this study was to determine the sensitivity, specificity, and predictive value of 13 symptoms for a discharge diagnosis o...

journal_title：Journal of the American Heart Association

authors： Devon HA,Rosenfeld A,Steffen AD,Daya M

更新日期：2014-04-02 00:00:00

abstract：BACKGROUND:Women have high rates of peripheral artery disease (PAD) despite fewer cardiovascular disease (CVD) risk factors, compared to men. We sought to determine the gender-specific prevalence of low ankle brachial index (ABI) and the relationship to C-reactive protein (CRP) levels and CVD risk factors in the Life L...

journal_title：Journal of the American Heart Association

authors： Hiramoto JS,Katz R,Weisman S,Conte M

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:History of gestational diabetes mellitus (GDM) increases lifetime risk of type 2 diabetes (DM) and the metabolic syndrome (MetS), which increase risk of cardiovascular disease. It is unclear, however, whether GDM increases risk of early atherosclerosis independent of pre-pregnancy obesity and subsequent meta...

journal_title：Journal of the American Heart Association

authors： Gunderson EP,Chiang V,Pletcher MJ,Jacobs DR,Quesenberry CP,Sidney S,Lewis CE

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Early reperfusion in the setting of an ST-elevation myocardial infarction (STEMI) is of utmost importance. However, the effects of early versus late reperfusion in this patient group undergoing primary percutaneous coronary intervention (PCI) have so far been inconsistent in previous studies. The purpose of ...

journal_title：Journal of the American Heart Association

authors： Koul S,Andell P,Martinsson A,Gustav Smith J,van der Pals J,Scherstén F,Jernberg T,Lagerqvist B,Erlinge D

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:Women are more likely than men to develop resistant hypertension, which is associated with excess risk of major adverse outcomes; however, the impact of resistant hypertension in women with ischemia has not been explicitly studied. In this Women's Ischemia Syndrome Evaluation (WISE) analysis, we assessed lon...

journal_title：Journal of the American Heart Association

authors： Smith SM,Huo T,Delia Johnson B,Bittner V,Kelsey SF,Vido Thompson D,Noel Bairey Merz C,Pepine CJ,Cooper-Dehoff RM

更新日期：2014-02-28 00:00:00

abstract：BACKGROUND:Fatty infiltration of the pancreas is an enigmatic manifestation of ectopic fat deposition in obesity. Studies have shown that pancreatic lipid accumulation interferes with insulin secretion in humans. However, the prevalence of fatty pancreas and its associated factors in the general population remain uncle...

journal_title：Journal of the American Heart Association

authors： Wang CY,Ou HY,Chen MF,Chang TC,Chang CJ

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:The American Heart Association (AHA) recently developed the Cardiovascular Health Index (CVHI), a health metric consisting of 7 modifiable risk factors. The relationship of the CVHI with preclinical markers, such as carotid intima-media thickness (CIMT) has not been assessed. METHODS:We examined 490 male mo...

journal_title：Journal of the American Heart Association

authors： Kulshreshtha A,Goyal A,Veledar E,McClellan W,Judd S,Eufinger SC,Bremner JD,Goldberg J,Vaccarino V

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Elevated albuminuria as well as an increased serum uric acid concentration is associated with poor cardiovascular outcome. We questioned whether these 2 variables (albuminuria and serum uric concentration) may be interrelated via tubular uric acid reabsorption. METHODS AND RESULTS:Included were 7688 partici...

journal_title：Journal of the American Heart Association

authors： Scheven L,Joosten MM,de Jong PE,Bakker SJ,Gansevoort RT,PREVEND study group.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Weight loss is associated with improvements in cardiometabolic risk factors, including serum glucose, insulin, C-reactive protein, and blood lipids. Few studies have evaluated the long-term (>18 months) effect of weight loss on these risk factors or sought to identify factors associated with sustained improv...

journal_title：Journal of the American Heart Association

authors： Dow CA,Thomson CA,Flatt SW,Sherwood NE,Pakiz B,Rock CL

更新日期：2013-12-18 00:00:00

abstract：BACKGROUND:Hemorrhagic risk assessment is a crucial issue in patients with nonvalvular atrial fibrillation (NVAF) who are receiving oral anticoagulant therapy (OAT). Our aim was to analyze the relationship between vitamin E, which possesses anticoagulant properties, and bleeding events in NVAF patients. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Pastori D,Carnevale R,Cangemi R,Saliola M,Nocella C,Bartimoccia S,Vicario T,Farcomeni A,Violi F,Pignatelli P

更新日期：2013-10-28 00:00:00

abstract：BACKGROUND:A cohort study found that 9/11-related environmental exposures and posttraumatic stress disorder increased self-reported cardiovascular disease risk. We attempted to replicate these findings using objectively defined cardiovascular disease hospitalizations in the same cohort. METHODS AND RESULTS:Data for ad...

journal_title：Journal of the American Heart Association

authors： Jordan HT,Stellman SD,Morabia A,Miller-Archie SA,Alper H,Laskaris Z,Brackbill RM,Cone JE

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:We investigated whether disease location influences survival in patients with peripheral arterial disease. METHODS AND RESULTS:Patients (n = 12,731; mean age, 67.5 ± 12.7 years; 57.4% male) who underwent outpatient noninvasive lower extremity arterial evaluation were followed up for 5.9 ± 3.1 years for all-...

journal_title：Journal of the American Heart Association

authors： Chen Q,Smith CY,Bailey KR,Wennberg PW,Kullo IJ

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Oxidative stress is implicated in the etiology of coronary heart disease (CHD). New measures to capture oxidative stress are warranted. Fluorescent oxidation products (FlOPs) can be measured in plasma and have been shown to reflect levels of oxidative stress and to predict risk of CHD in men over 6 years of ...

journal_title：Journal of the American Heart Association

authors： Jensen MK,Wang Y,Rimm EB,Townsend MK,Willett W,Wu T

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Our laboratory has previously demonstrated the importance of a cytoskeletal-based survival signaling pathway using in vitro models of ischemia/reperfusion (IR). However, the importance of this pathway in mediating stress-elicited survival signaling in vivo is unknown. METHODS AND RESULTS:The essential cytos...

journal_title：Journal of the American Heart Association

authors： Perricone AJ,Bivona BJ,Jackson FR,Vander Heide RS

更新日期：2013-09-30 00:00:00

abstract：BACKGROUND:The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as...

journal_title：Journal of the American Heart Association

authors： Thomas KL,Piccini JP,Liang L,Fonarow GC,Yancy CW,Peterson ED,Hernandez AF,Get With the Guidelines Steering Committee and Hospitals.

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Transseptal puncture is a critical step in achieving left atrial (LA) access for a variety of cardiac procedures. Although the mechanical Brockenbrough needle has historically been used for this procedure, a needle employing radiofrequency (RF) energy has more recently been approved for clinical use. We soug...

journal_title：Journal of the American Heart Association

authors： Hsu JC,Badhwar N,Gerstenfeld EP,Lee RJ,Mandyam MC,Dewland TA,Imburgia KE,Hoffmayer KS,Vedantham V,Lee BK,Tseng ZH,Scheinman MM,Olgin JE,Marcus GM

更新日期：2013-09-17 00:00:00

abstract：BACKGROUND:Vascular calcification is a common feature in patients with chronic kidney disease (CKD). CKD increases serum levels of tumor necrosis factor-α (TNFα), a critical mediator of vascular calcification. However, the molecular mechanism by which TNFα promotes CKD-dependent vascular calcification remains obscure. ...

journal_title：Journal of the American Heart Association

authors： Masuda M,Miyazaki-Anzai S,Levi M,Ting TC,Miyazaki M

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inh...

journal_title：Journal of the American Heart Association

authors： Green EA,Raj V,Shibao CA,Biaggioni I,Black BK,Dupont WD,Robertson D,Raj SR

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA). METHODS AND RESULTS:This is a retrospective, observational, single-ce...

journal_title：Journal of the American Heart Association

authors： Sato K,Kaikita K,Nakayama N,Horio E,Yoshimura H,Ono T,Ohba K,Tsujita K,Kojima S,Tayama S,Hokimoto S,Matsui K,Sugiyama S,Yamabe H,Ogawa H

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:A high consumption of omega-3 long-chain polyunsaturated fatty acids, and particularly docosahexaenoic acid (DHA), has been suggested to reduce the risk of cardiovascular disease (CVD). However, while DHA supplementation may have benefits for secondary prevention, few studies have investigated the role of DH...

journal_title：Journal of the American Heart Association

authors： Singhal A,Lanigan J,Storry C,Low S,Birbara T,Lucas A,Deanfield J

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Short-term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate-matter (PM) have been related with increased blood pressure (BP) in controlled-human exposure and community-based studies. However, whether coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent observational studies...

journal_title：Journal of the American Heart Association

authors： Bellavia A,Urch B,Speck M,Brook RD,Scott JA,Albetti B,Behbod B,North M,Valeri L,Bertazzi PA,Silverman F,Gold D,Baccarelli AA

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:We aimed to determine how single and combination antihypertensive therapy alters risk for diabetes mellitus (DM).Thiazide diuretics (TD), β blockers (BB), and renin-angiotensin system blockers (RASB) impact DM risk while calcium channel blockers (CCB) are neutral. DM risk associated with combinations is uncl...

journal_title：Journal of the American Heart Association

authors： Cooper--DeHoff RM,Bird ST,Nichols GA,Delaney JA,Winterstein AG

更新日期：2013-06-10 00:00:00

abstract：BACKGROUND:Acute end points of catheter ablation for ventricular tachycardia (VT) remain incompletely defined. The aim of this study is to identify causes for failure in patients with structural heart disease and to assess the relation of this acute outcome to longer-term management and outcomes. METHODS AND RESULTS:F...

journal_title：Journal of the American Heart Association

authors： Tokuda M,Kojodjojo P,Tung S,Tedrow UB,Nof E,Inada K,Koplan BA,Michaud GF,John RM,Epstein LM,Stevenson WG

更新日期：2013-05-31 00:00:00